Protein Purification
MilliporeSigma™ Calbiochem™ Citalopram Hydrobromide
A potent uptake inhibitor highly selective for 5-HT transporter without effect on noradrenalin or dopamine uptake (IC50
MilliporeSigma™ Calbiochem™ BMI-1 Expression Inhibitor, PTC-209
A cell-permeable compound that downregulates cellular BMI-1 levels by inhibiting BMI-1 transcription.
MilliporeSigma™ Calbiochem™ MICAL-2 Inhibitor II, CCG-203971
A cell-permeable, restricted form of CCG-1423 with enhanced potency (IC50 = 4.2 μM vs 16.6 μM for PC-3 cell migration), but reduced off-target toxicity.
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor IV
A cell-permeable inhibitor of SKP2-dependent p27Kip1 ubiquitination. Selectively induces the accumulation SCFSKP2 substrates in multiple myeloma RPMI 8226 cells.
MilliporeSigma™ Calbiochem™ Porcn Inhibitor IV, LGK974
A cell-permeable inhibitor of Wnt secretion from L-cell Wnt1/2/3/3a/6/7a/9a transfectants (IC50 from 50 pM to 1.1 nM).
MilliporeSigma™ Calbiochem™ EGFR Activator, NSC 228155
A nitro-benzoxadiazole compound that directly binds to the dimerization domain of sEGF receptor to generate stable dimers and allosterically activate the receptor.
MilliporeSigma™ Calbiochem™ DUB Inhibitor XI
A cell-permeable compound that acts as a dual inhibitor of USP7 (IC50 = 0.42 μM) and USP47 (IC50 = 1.0 μM).
MilliporeSigma™ Calbiochem™ α-Synuclein Blocker, ELN484228
A cell-permeable compound that reversibly binds to pocket I of the monomeric α-synuclein (α-syn) and reverses α-syn-induced impairment of phagocytosis in H4 neuroglioma cells.
MilliporeSigma™ Calbiochem™ IRAP Inhibitor, HFI-419
A substrate competitive inhibitor of insulin-regulated aminopeptidase (IRAP) activity (Ki = 0.48 μM against 25 μM Leu-AMC).
MilliporeSigma™ Calbiochem™ InSolution™ Ginkgolic Acid (15:1)
A 25 mM (2 mg/231 μl) sterile-filtered solution of Ginkgolic Acid (15:1) in DMSO.
MilliporeSigma™ Calbiochem™ TNF-TNFR Interaction Modulator, C87
Inhibits TNFα/β-stimulated biological activity by modulating, but not abolishing, TNF-TNFR interaction via direct TNF affinity interaction (KD = 110 nM).
MilliporeSigma™ Calbiochem™ RNA Polymerase I Inhibitor II, CX-5461
A cell-permeable, selective inhibitor of RNA polymerase I-mediated pre-rRNA transcription (IC50 = 142 nM in HCT-116 cells).
Cytiva™ HiTrap™ Chromatography Columns with MabSelect™ VL Protein L Resin
Protein L affinity chromatography columns for capture of antibody Fabs, bispecifics, and other variants containing a kappa light chain.
Cytiva™ HiTrap™ Capto™ Adhere
The HiTrap Capto adhere is prepacked with a strong anion exchange multimodal resin for removing contaminants in post-protein A purification.
MilliporeSigma™ Calbiochem™ InSolution™ (+)-Brefeldin A, Eupenicillium brefeldianum
A 25 mM solution of (+)-Brefeldin A in DMSO.